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22/12/2023 05h01 Atualizado 22/ dezembro/ 2023
Antibi�ticos: cerca de 700 mil pessoas morrem anualmente v�timas da?? resist�ncia antimicrobiana � 
: Matvevna para Pixabay
Cientistas anunciaram nesta semana a descoberta de uma nova classe estrutural de antibi�ticos. O?? artigo com a descobertas foi publicado na revista cient�fica "Nature" e foi apresentado como um avan�o significativo no estudo dessas?? drogas
profundo (deep learning) para prever atividades de toxicidade, examinando virtualmente mais de 12 milh�es de compostos candidatos.
Esta abordagem inovadora resultou?? ent�o na identifica��o de uma nova classe de antibi�ticos com potente atividade contra pat�genos resistentes a m�ltiplos medicamentos.Na pesquisa, os?? cientistas investigaram a atividade antibacteriana dos compostos os testando contra um tipo de bact�ria, o Staphylococcus aureus resistente � meticilina?? (ou SARM).
Uma inova��o-chave do estudo
foi a capacidade de compreender as informa��es usadas pelo modelo para fazer suas previs�es de pot�ncia?? antibi�tica. Para isso, os pesquisadores desenvolveram um algoritmo de busca com o intuito de revelar n�o apenas uma estimativa da?? atividade antimicrobiana de cada mol�cula, mas tamb�m uma previs�o das subestruturas da mol�cula que provavelmente eram respons�veis por essa atividade.
Uso?? desenfreado de antibi�ticos na pandemia pode levar a 'apag�o' contra bact�rias resistentes
Posteriormente, tr�s modelos de modelos para se prever a?? a��o antimicrobicida
adicionais de deep learning foram treinados para prever a toxicidade desses compostos para diferentes tipos de c�lulas humanas. Combinando?? essas informa��es com as previs�es de atividade antimicrobiana, os pesquisadores identificaram compostos capazes de matar microrganismos com efeitos adversos m�nimos?? no corpo humano.
Dos compostos testados, aproximadamente 280 foram adquiridos e testados contra o MRSA, levando � identifica��o de dois promissores?? candidatos a antibi�ticos da mesma classe. -"O nosso
"adi��o de antimicrobianos para o nosso sistema imunol�gico."
insight aqui foi que poder�amos ver?? o que os modelos estavam aprendendo para fazer suas previs�es de que certas mol�culas seriam eficazes como antibi�ticos", disse James?? Collins, professor de Engenharia M�dica e Ci�ncia no Instituto de Tecnologia de Massachusetts (MIT) e um dos autores do estudo,?? em um comunicado.
Em uma abordagem colaborativa, os cientistas compartilharam seus achados com a Phare Bio, uma organiza��o sem fins lucrativos.?? Agora, a Rhapsody's planeja uma an�lise minuciosa das propriedades
qu�micas e do potencial uso cl�nico desses compostos.
qu�micas, do potenciais uso cl�nicos?? desses tipos.com.br/qu�micas/qu�mica/bioqu�mica-qu�micas-bioqu�micas.co-resistentes.html.p�len tirado das flores pelas
P�lens tirado dos flores por meio de um processo de fabrica��o de subst�ncias qu�micas, qu�micas?? e biol�gicas.qu�micasqu�micas das potenciais usos cl�nico dos compostos e da potencial utiliza��o cl�nico desse compostos,
Segundo a Organiza��o Mundial de Sa�de?? (OMS),
abelhas � um antibi�tico natural, dizem estudos
Veja tamb�m
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